Considering the marked hypoferremia and hyperphosphatemia observed in the conditional‐null mice, although the Dmp1‐Cre is known to efficiently recombine the flox‐Fgf23 allele (Clinkenbeard et al., 2016), the sum of both of these systemic Fgf23 drivers may override the suppressive abilities of the targeted deletion. Here, DMP1 is linked to hyperphosphatemia.