To determine the roles of FGF23 versus iron handling on CKD phenotypes, a flox‐Fgf23 allele was targeted for conditional deletion in late‐stage osteoblasts and osteocytes by breeding flox‐Fgf23 conditional mice to the Dmp1‐Cre transgenic line to create flox‐Fgf23/Dmp1‐Cre+/− mice as previously described (Clinkenbeard et al., 2016). Here, FGF23 is linked to chronic kidney disease.