Hyperphosphatemia in CKD, which results from the disruption of phosphate excretion and renal ultrastructural damage, also increases odds for adverse renal and cardiovascular outcomes (Block et al., 2019; Isakova, 2011), and in dialysis patients, elevated circulating FGF23 is also an independent risk factor for mortality (Ganz et al., 2019; Isakova, 2011). This evidence concerns the gene FGF23 and hyperphosphatemia.