Interestingly, expression of recombinant V3 in U2OS cells or endogenous V3 in the ALK-positive NSCLC patient cell line, H2228, leads to altered cell morphology with elongated cytoplasmic protrusions as well as enhanced cell migration, potentially as a result of increased microtubule stabilization (20). The gene discussed is ALK; the disease is non-small cell lung carcinoma.