PINK1 and Parkinson disease: Yang et al. generated PTEN-induced kinase 1 (PINK1, whose mutations cause early-onset Parkinson’s disease (PD) mutant monkeys by targeting two exons in the PINK1 gene (Yang et al., 2019a; Yang et al., 2019b), which showed remarkable neuronal loss in the cortex, substantia nigra and striatum.