Afterwards, in 2008, Yang et al. developed a transgenic model of Huntington’s disease (HD) in a rhesus macaque that expressed polyglutamine (polyQ)-expanded huntingtin protein (HTT) by injecting lentiviral vector into mature rhesus oocytes followed by fertilization through intracytoplasmic sperm injection and embryo transplantation (Yang et al., 2008). This evidence concerns the gene HTT and Huntington disease.