LMNA and Hutchinson-Gilford progeria syndrome: As for NHPs, researchers generated the first Hutchinson-Gilford progeria syndrome (HGPS) monkey model by delivering a BE mRNA and guide RNA (gRNA) targeting the LMNA (lamin A/C) gene via microinjection into monkey zygotes, and the typical HGPS phenotypes including growth retardation, bone alterations, and vascular abnormalities confirmed the reliability of this model (Wang et al., 2020).