By using BE3 to target the TWIST2 (twist-related protein 2) gene [responsible for the ablepharon macrostomia syndrome (AMS) in human)] and the tyrosinase (TYR) gene [the causal gene for oculocutaneous albinism type 1 (OCA1)], researchers created a gene editing pig model successfully in the same year of the first base editing goats (Li Z. et al., 2018), which mimicked the phenotypic characteristics of human diseases well. This evidence concerns the gene TWIST2 and ablepharon macrostomia syndrome.