TYR and ablepharon macrostomia syndrome: By using BE3 to target the TWIST2 (twist-related protein 2) gene [responsible for the ablepharon macrostomia syndrome (AMS) in human)] and the tyrosinase (TYR) gene [the causal gene for oculocutaneous albinism type 1 (OCA1)], researchers created a gene editing pig model successfully in the same year of the first base editing goats (Li Z. et al., 2018), which mimicked the phenotypic characteristics of human diseases well.