Boudreau et al. revealed that laminopathy mutants resulted in the mislocalization of SUMO1 both in vitro and in vivo, suggesting that the mutant lamin A/C altered the dynamics of SUMO1, and thus, misregulation of SUMOylation may be contributing to disease progression in laminopathies (Boudreau et al., 2012). The gene discussed is SUMO1; the disease is laminopathy.