LMNA and Hutchinson-Gilford progeria syndrome: LMNA mutations are associated with diverse pathological conditions including muscular dystrophy (such as Emery–Dreifuss muscular dystrophy (EMD), limb-girdle muscular dystrophy 1B (LGMD1B) and dilated cardiomyopathy (DCM)), lipodystrophy, neuropathy, and progeroid syndromes (such as Hutchinson–Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD)) (Dechat et al., 2008; Parnaik, 2008; Prokocimer et al., 2009; Dechat et al., 2010; Dittmer and Misteli, 2011; Parnaik et al., 2011; Ho and Lammerding, 2012; Burke and Stewart, 2013).