Increased release of BDNF and enhanced TrkB signaling may be responsible for the induction of PI3K/Akt/mTOR and favorable effects on inflammation, apoptosis, anxiety-related behavior, and cognitive improvement seen in the present study after iTBS (Stevanovic et al., 2019; Lee et al., 2021; Uzair et al., 2022). This evidence concerns the gene BDNF and Anxiety.