Together, our data demonstrate a central role for PD-L1 in mediating some of IFNγ metabolic and transcriptional effect in ccRCC cells and provides a rationale to further study how immunotherapies affect ccRCC metabolism and whether the efficacy of ICIs, including development of ICIs resistance in ccRCC, could be monitored by imaging ccRCC metabolism. The gene discussed is IFNG; the disease is nonpapillary renal cell carcinoma.