Together, our data demonstrate a central role for PD-L1 in mediating some of IFNγ metabolic and transcriptional effect in ccRCC cells and provides a rationale to further study how immunotherapies affect ccRCC metabolism and whether the efficacy of ICIs, including development of ICIs resistance in ccRCC, could be monitored by imaging ccRCC metabolism. This evidence concerns the gene CD274 and nonpapillary renal cell carcinoma.