In concordance with these results, these PD-L1 antibodies increased caspase 3/7 activity in both ccRCC cells when compared to their isotype control (Figure 5C), indicating induction of apoptosis in A498 and 786-O by CTLs in the presence of PD-L1 blockers. This evidence concerns the gene CASP3 and nonpapillary renal cell carcinoma.