As shown in Figure 4A, silencing of PD-L1 significantly dampened the overall transcriptional effect of IFNγ on ccRCC cells when comparing IFNγ-exposed samples that were transfected with either Cnsi (control siRNA) or PD-L1si (PD-L1 siRNA). The gene discussed is CD274; the disease is nonpapillary renal cell carcinoma.