In a mouse model of lung adenocarcinoma, triple therapy with the RadScopal approach (high-dose radiation to primary tumors plus low-dose radiation to secondary tumors) plus anti-TIGIT and plus anti-PD-1 prolong survival and block tumor growth while decreasing TIGIT+ exhausted T cells and TIGIT+ Tregs (104). This evidence concerns the gene TIGIT and lung adenocarcinoma.