Furthermore, in the same study for cervical cancer was observed that the advanced T cell differentiation (CD27–CCR7–CD45RA–) of PD-1+TIGIT+2B4+TIM3+KLRG-1–CTLA4– CD8+ TILs was associated with 60% of poorly differentiated cervical cancer (128). The gene discussed is CTLA4; the disease is cervical carcinoma.