In various cancers, according to computational analyses, the TIGIT expression profile was related to the immune infiltration level, coupled with the expression of other IRs, including LAG3, CTLA4, PD-1, PD-L1, PD-L2, and it is related to tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), and DNA methyltransferases (DNMTs) gene alterations in different tumors (122). Here, CD274 is linked to neoplasm.