The expression pattern of immune checkpoints on NK cells isolated from peripheral blood of patients affected by hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) revealed a positive correlation among the co-expression of TIGIT and TIM3 in exhausted T cells, high rate of tumor progression, and poor clinical prognosis (144). The gene discussed is HAVCR2; the disease is hepatocellular carcinoma.