Artesunate-induced autophagy was well demonstrated in human bladder cancer cells, upregulating ROS and activating the AMPK-mTOR-ULK1 axis and in uterine corpus endometrial carcinoma, enhancing NK cell cytotoxicity via interactions with tumor cells overexpressing CD155, and upregulating co-stimulator CD226 and downregulating co-inhibitor TIGIT (176–178). The gene discussed is CD226; the disease is neoplasm.