In colorectal cancer cell line CT26 and breast cancer cell line 4T1 and in their in vivo mouse models, TIGIT and HIF-1α down-regulation diminished the colony formation ability and afflicted cancer cells’ angiogenesis and proliferation activities, suggesting simultaneous blocking of TIGIT and HIF-1α as a potential new treatment strategy (166). The gene discussed is HIF1A; the disease is colorectal cancer.