PET imaging with i.v. injected [64Cu]Cu–GTSM demonstrated increased 64Cu brain uptake in the βPP/PS1 mouse model of Alzheimer's disease (AD).217 Using the same approach, changes in the 64Cu clearance kinetics and brain biodistribution of 64Cu were reported in two neurodegeneration mouse models: the TASTPM model of AD218 (Fig. 10) and in mice modelling Niemann-Pick C disease,219 a genetic lysosomal storage disorder. This evidence concerns the gene SRPX2 and Alzheimer disease.