Disruption of manganese homeostasis can lead to overload and toxicity, i.e. manganism, a parkinsonian-like movement disorder characterised by chronic overload of manganese in the basal ganglia of the brain.57–59 Mutations in manganese transporters such as SLC30A10 (ZnT10) and SLC39A14 (ZIP14) disrupt the normal regulation of manganese absorption in the gut and excretion from the liver respectively. The gene discussed is SLC39A14; the disease is manganese poisoning.