A total of 172 statistically significant SHCJ-AD-related pathways were obtained (P ≤ 0.05), with the top 30 significantly enriched ones having high gene counts shown as the core pathways in Figure 6, including lipid and atherosclerosis (n = 43), Kaposi sarcoma-associated herpesvirus infection (n = 34), chemical carcinogenesis-receptor activation (n = 34), PI3K-Akt signaling pathway (n = 34), and hepatitis B (n = 33). This evidence concerns the gene AKT1 and Alzheimer disease.