The results showed that catgut implantation at acupoints could upregulate the expression of OB-Rb mRNA in the hypothalamus of obese rats and reduce the expression of SOCS-3 mRNA in hypothalamus cells and the content of SOCS-3 in peripheral blood serum, which suggested that catgut implantation at acupoints promoted signal transduction after LP and fasting insulin receptors, improved leptin resistance (LR) and insulin resistance (IR), and promoted LP and fasting insulin to exert biological effects. This evidence concerns the gene RB1 and Insulin resistance.