Zhang et al. showed that flavonoids inhibit cell proliferation and induce apoptosis and autophagy through down-regulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells, they found that flavonoids induced cell cycle arrest at G2/M phase, apoptosis, and autophagy (39). This evidence concerns the gene AKT1 and breast cancer.