AKT1 and cancer: Similarly, both flavonoid compounds (baicalein and baicalin) caused autophagy in various cancers including cleavage of LC3, autophagic flux, autophagosome formation and activation of Atg5/Atg7, Beclin-1, and vacuolar protein sorting 34, involvement of AKT/mTOR pathway, and activation of RelB/p52 proteins (123-128).