HK2 and acute lymphoblastic leukemia: Figures 2D-F demonstrated that enforced expression of MAGI2-AS3 promoted glucose uptake, lactate, and ATP release. Moreover, Western blotting analysis showed that PCNA, Bcl-2, and HK2 were down-regulated, but Bax was up-regulated in MAGI2-AS3-overexpressed ALL cells (Figure 2G-I).