CLDN5 and ischemic stroke: The combination of Puerariae Lobatae Radix and Chuanxiong Rhizoma protected the brain-gut barriers by increasing claudin-5 and ZO-1 levels, weakened the gut microbiota translocation by decreasing diamine oxidase, lipopolysaccharide and d-lactate, and effectively improved the neurological function after ischemic stroke.