Previous studies have demonstrated that ITGAM (integrin αM) and ITGB2 (integrin β2) can promote leukocyte transendothelial migration and disrupt endothelial barrier function through animal and cultured cells experiments (23, 24), and some studies have reported that ITGB2 and ITGAM may be involved in the progression of atherosclerosis through bioinformatics analysis (25, 26). The gene discussed is ITGAM; the disease is atherosclerosis.