Our results showed that UHRF1 gene expression was correlated with four methyltransferases (DNMT1, DNMT2, DNMT3A, and DNMT3B) in a variety of tumors, and KICH KIRC KIRP was positively correlated with methyltransferase, suggesting that UHRF1 may be an epigenetic driver of renal cancer type. The gene discussed is DNMT3A; the disease is renal carcinoma.