On the other hand, we obtained that UHRF1 was positively correlated with TMB in BLCA and OV, and the combination of tumor mutation load (TMB) and copy number change (CNA) could be used to group a variety of metastatic tumors, and the optimal treatment subgroup could be selected according to the prognosis of different groups [43]. The gene discussed is UHRF1; the disease is neoplasm.