In this study, we analyzed the association between UHRF1's ubiquitous-expression methylation analysis of tumor-infiltrating immune cells (TIIC) and associated immune markers by data mining from a variety of databases and visualized its prognostic status in ubiquitous-cancer findings UHRF1 affects the prognosis of cancer patients, probably through its interaction with immune infiltration and methylation modification. This evidence concerns the gene UHRF1 and cancer.