Previous studies have suggested that regulation of tumor immune escape via the RP11-424C20.2/UHRF1 axis plays a different role in the progression of hepatocellular carcinoma (LIHC) and thymoma (THYM) and is associated with IFN-γ-mediated CLTA-4 and PD-L1 pathways [41]. This evidence concerns the gene UHRF1 and hepatocellular carcinoma.