In the GEPIA2 online database, combined with the TCGA and GTEx datasets, the differential expression analysis showed that SETDB1 was highly expressed in the thymoma (THYM), lower grade glioma (LGG), acute myeloid leukemia (LAML), GBM, lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), and CHOL, while it was lowly expressed in THCA, prostate adenocarcinoma (PRAD), KICH, and adrenocortical carcinoma (ACC) and was not expressed in other cancers (Figure 4(b)). The gene discussed is SETDB1; the disease is central nervous system cancer.