In current study, we investigated the pan-cancer alterations of PPP1R14A using the cBioPortal (TCGA, Pan-Cancer Atlas) database and demonstrated that the alteration frequency of PPP1R14A was 2.3% across 32 various cancers and was prominent, 16.07% in samples of uterine carcinosarcoma. This evidence concerns the gene PPP1R14A and cancer.