For instance, EMT and glomerulosclerosis in rats with chronic kidney disease were suppressed by JAK/STAT signaling pathway (Zhao et al., 2019), and cyclosporine-A-induced renal fibrosis was ameliorated by chrysin by the inhibition of TGF-beta-induced EMT (Nagavally et al., 2021). This evidence concerns the gene SOAT1 and renal fibrosis.