MTOR and Hepatic fibrosis: In a recent study, researchers demonstrated that mammalian target of rapamycin (mTOR), an inhibitor of autophagy, actually promotes HSC activation and liver fibrosis through extracellular vesicle (EV) release, while restoring autophagy in HSCs attenuates liver fibrosis by inhibiting the release of fibrogenic EVs(Gao et al., 2020).