PF4 and Hepatic fibrosis: For instance, the overexpression of CCR1, CCR5, and CXCL4 can contribute to progression of liver fibrosis, whereas the stimulation of CXCR3 and CXCL9 exert the protective function of liver fibrosis (Bruns et al., 2014; Arsent’eva et al., 2015; Ambade et al., 2019).