Primed CD8+ T cells subsequently recognize the neoantigens presented by tumor cells through the major histocompatibility complex (MHC) or human leukocyte antigen (HLA) class I molecules, resulting in elimination of tumor cells (Croft et al., 1994; Wculek et al., 2020; Jhunjhunwala et al., 2021). This evidence concerns the gene HLA-C and neoplasm.