Th2 cells concretely activated by allergens via secreting Th2 cytokines IL-4, IL-5 and IL-13, amplify type II inflammation, while T helper 1 (Th1) cells by secreting Th1 cytokines such as IFN-γ, IL-2, lymphotoxin (LT)-α and tumor necrosis factor (TNF)-α and so on, limit type II inflammation and mediate type I inflammation (Foster et al., 2017; Mukherjee and Nair, 2018), which causing childhood asthma. The gene discussed is TNF; the disease is childhood onset asthma.