IGHE and allergic disease: This drives B cells to produce a large number of IgE that cross-linking causes degranulation of mast cells to produce a series of inflammatory mediators such as leukotrienes, endothelin, prostaglandin and thromboxane A2, etc. and eventually induce rapid onset (increased IgE) allergies and eosinophilic airway inflammation (Bégin and Nadeau, 2014; Chogtu et al., 2016; McCracken et al., 2016).