Examples of pathways or networks that are implicated by GWASs in asthma are the IL33-IL1-RL1 receptor pathway, leading to eosinophilia, and the T-helper-2 (Th2) cytokine IL-5 and IL-4RA receptor, leading to eosinophilia and type 2 inflammation or viral response (CDHR3, ORMDL3) (Zhang et al., 2019a; Basnet et al., 2019). Here, ORMDL3 is linked to Increased total eosinophil count.