IL17A and obesity due to melanocortin 4 receptor deficiency: However, non-Th2-type asthma related to non-allergic asthma, which is characterized by emotion, obesity, environmental factors, such as air pollution including ozone, cigarette smoke and so on, may release cytokines such as Il-17 and IFN-γ by activation of Th1 cells, leading to neutrophilic inflammation, M1 macrophage, NKT cell recruitment to the airways and AHRs (Castan et al., 2020; Agache et al., 2021).