However, the expression of the chondrogenic marker gene (SOX-9, aggrecan, Col I, Col II) significantly increased at day 5 and sGAG enlarged from days 7–14 in the AD-MSCs of the scaffold, revealing the potential chondrogenic differentiation of AD-MSCs (Nedunchezian et al., 2021). This evidence concerns the gene SOX9 and Alzheimer disease.