These findings are consistent with those reported previously by Kurmyshkina et al. 2017, who showed in H-SIL and CC patients a significant up-regulation in the levels of circulating CD3+CD95+ (Fas) and CD4+CD95+ in T lymphocytes, that also were positive for the apoptosis marker annexin-V, with respect to healthy donors, suggesting that CD95-dependent pathway could be associated with CC development (45). The gene discussed is ANXA5; the disease is squamous cell intraepithelial neoplasia.