Additionally, the increased expression levels of Fas and FasL at a systemic level and on the surface of T lymphocytes, and the higher cervical levels of FasL in CC patients suggest that HPV-transformed cells could remove tumor-infiltrating lymphocytes (TILs); this is further supported by the lower systemic, but higher cervical FasL levels in CC cases, which may target Fas-expressing T lymphocytes, inducing cell death by apoptosis. This evidence concerns the gene FAS and neoplasm.