Considering the effective role of estrogen in impeding AKI and also the positive effects of TR and CR diets in preventing diseases, the objectives of the present study in postmenopausal model of rats included determining the effects of the diets mentioned above on the severity of glycerol induced AKI through histopathological indices, as well as determining the role of Bax and Bcl2 molecules involved in apoptosis after AKI. This evidence concerns the gene BAX and acute kidney injury.