GPC3 and hepatocellular carcinoma: In the EZH2 related sub-network, three miRNAs (hsa-miR-527, hsa-miR-518a-5p, and hsa-miR-217-5p) interacted with EZH2. It has been reported that miR-527 may be involved in the progression of HCC by targeting Glypican-3 (48).