More concretely, SCA14 has a frequency of 1-4% of families with SCA and is caused by a missense mutation or deletion of the PRKCG gene to induce neurotoxic amyloid-like fibril protein kinase Cγ (PKCγ) aggregate and affect cerebellar Purkinje cells [62]. The gene discussed is PRKCG; the disease is autosomal dominant cerebellar ataxia.