The calcineurin/NFAT signaling-dependent activation of Utrophin A also ameliorates the DMD phenotype in mdx mice [91]; however, pharmacological inhibition of cyclosporin A [92] on calcineurin resulted in inhibition of PPARδ-mediated changes in myofiber metabolism, indicating cross-interference between these different pathways. The gene discussed is PPARD; the disease is Duchenne muscular dystrophy.