The possible immune system abnormalities in ME/CFS could include higher production of pro-inflammatory cytokines (i.e.,IL-4, IL-5, IL-6, IL-12), immunosuppression due to dysfunctional natural killer cells (NK), decreased function of T cells (e.g. CD8+ and CD4+), and increased production of autoantibodies (e.g., rheumatic factor, anti-thyroid) [25, 44-46]. The gene discussed is IL6; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.