PI3 and Alzheimer disease: Yi et al. [96] (Figure ) found that lncRNA MEG3 is down-regulated in AD rat tissues, and up-regulated MEG3 can inhibit oxidative stress injury and inflammatory injury of AD rats, inhibit pathological injury and apoptosis of hippocampal neurons, and reduce the positive expression of Aβ via inactivation of the PI3/Akt pathway, thereby improving spatial learning and memory ability of mice.