CDK5R1 and Alzheimer disease: In 2018, Spreafico et al. observed that the expression abundance of NEAT1 was up-regulated in the temporal cortex and hippocampus of AD patients, and there was a close positive correlation between the abundance of CDK5R1 and NEAT1 in nerve tissues, indicating that NEAT1 may have a neuroprotective effect to compensate for the increased level of CDK5R1 [48].