VEGFA and Stroke: Another study found that recombinant ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) inhibited the up-regulation of VEGF in vascular endothelial cells after stroke through the Akt/rhoa-mediated VEGF pathway, regulated BBB integrity and reduced tPA -induced hemorrhage transformation [32].