CASP8 and breast cancer: In the BC group, 17 genes among these DEGs (IL6, TP63, ELANE, NLRP1, PJVK, GSDME, NLRP3, NOD1, IL1B, CASP1, CASP4, CHMP3, SCAF11, GPX4, IRF2, TIRAP, and PLCG1) were downregulated, while 21 other genes (CASP8, CHMP6, GSDMB, CHMP4C, CHMP2A, CHMP4B, CYCS, CASP3, IRF1, CASP6, BAK1, GSDMD, GZMA, BAX, IL18, NLRP6, NOD2, PYCARD, AIM2, GSDMC, and NLRP7) were upregulated compared with adjacent breast tissues.