TRPV1 and hereditary sensory and autonomic neuropathy: To examine the involvement of TRPV1 channels and related signaling factors in hyperalgesia and AI-mediated analgesia, changes in expression were examined by western blotting of DRG and SC tissue samples isolated after successful induction of hyperalgesia by CIP after reversal by AI (as confirmed by von Fey and Hargreaves’ tests).