In accordance with findings in DRG and SC, there were significant increases in the expression levels of TRPV1 (Figures 4A, 5A), pPKA (Figures 4B, 5B), pPI3K (Figures 4C, 5C), pPKC (Figures 4D, 5D), pERK (Figures 4E, 5E), pJNK (Figures 4F, 5F), pp38 (Figures 4G, 5G), pAkt (Figures 4H, 5H), pmTOR (Figures 4I, 5I), pCREB (Figures 4J, 5J), pNFκB (Figures 4K, 5K), Nav1.7 (Figures 4L, 5L), Nav1.8 (Figures 4M, 5M), Iba1 (Figure 4N, 5N), S100B (Figure 4O, 5O), and RAGE (Figures 4P, 5P) following CIP induction. Here, SCN10A is linked to hereditary sensory and autonomic neuropathy.