In MafA-/- mice, insulin 1, insulin 2, PDX-1, neurogenic differentiation (NeuroD) and glucose transporter 2 (GLUT2) amounts are reduced, and glucose, arginine and KCl-induced insulin secretion are remarkably altered (16) Thus, PDX-1 and MafA may be important factors in diabetes therapy. This evidence concerns the gene INS and diabetes mellitus.