Among these targets, albumin (ALB), Interleukin-6(IL6), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), AKT1, tumor necrosis factor (TNF), vascular endothelial growth factor A (VEGFA), tumor antigen gene p53(TP53), proto-oncogene tyrosine-protein kinase SRC (SRC), caspase-3 (CASP3), and signal transducers and activators of transcription3 (STAT3) were the core targets of the E. ulmoides leaf extract to suppress hyperuricemia and UA-induced inflammation. This evidence concerns the gene TNF and hyperuricemia.