As it has been reported that patients with heterozygous FH show an increase by 20-fold in the incidence of ASCVD without any medication intervention [26] and heterozygous LDLR-deficient hamsters are predisposed to diet-induced atherosclerosis [15], we crossed Idol−/− into LDLR-deficient background to generate Idol−/−LDLR+/- hamsters, which were fed with HFD for 16 weeks. The gene discussed is LDLR; the disease is atherosclerosis.