Consistently, HFD-fed Idol−/−LDLR+/- and LDLR+/- hamsters showed identical atherosclerotic lesion areas in the aortic roots and the whole aortas (Figures 5(c) and 5(d)), suggesting that inactivation of Idol did not affect diet-induced hyperlipidemia and atherosclerosis in the presence of one copy of Ldlr in hamsters. This evidence concerns the gene LDLR and atherosclerosis.