Ou et al. found that Lut induces apoptosis in ccRCC cells (i.e., 786-O, A498, and ACHN), and this apoptosis is mediated by the downregulation of Akt and the upregulation of apoptosis signal-regulated kinase-1, p38, and c-Jun N-terminal kinase activity probably via protein phosphatase 2A activation [38]. Here, MAP3K5 is linked to nonpapillary renal cell carcinoma.