By contrast, the data of the current study suggests that Lut activates the NRF2/HO-1 axis in ccRCC and that the deteriorating effect caused by HO-1 overactivity has exceeded the antiferroptosis effect of the NRF2/SLC7A11 axis, ultimately accounting for the downregulation of SLC7A11 and initiation of ferroptosis. This evidence concerns the gene SLC7A11 and nonpapillary renal cell carcinoma.