CDK4 and colorectal carcinoma: The photographs of IHC showed that CRC tissues with a low level of circTMEM59 had higher expressions of Bcl-2, CDK4, Vimentin, and cyclin D1 and lower expressions of ID4, caspase-3, and E-cadherin compared with the high level of circTMEM59 expression in tumors of CRC (Figure 2(h) and Figure S1A).