Combined with clinical data, IHC results showed that CRC tissues with a low level of circTMEM59 had higher expressions of Bcl-2, CDK4, cyclin D1, and Vimentin and lower expressions of ID4, caspase-3, and E-cadherin compared with the high level of circTMEM59 in CRC tissues (Figure 2). The gene discussed is CDK4; the disease is colorectal carcinoma.