CDK4 and colorectal carcinoma: The results of IHC showed that the CRC tissues with high miR-668-3p presented more proliferation and metastasis-related proteins (upregulated CDK4, cyclin D1, ki-67, and Vimentin and downregulated ID4 and E-cadherin) and less apoptosis-related proteins (upregulated Bcl-2 and downregulated caspase-3) than CRC tissues with low miR-668-3p (Figure 3(g)).