Castillo et al. treated rats with quercetin (0.5% w/w) for 4 weeks and then observed quercetin counteracted hyperglycemia-induced bioenergetic deterioration, including avoiding cardiac cholesterol accumulation, accompanied by upregulating Nrf2, HO-1, SOD, and proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) [51]. The gene discussed is NFE2L2; the disease is Hyperglycemia.