Furthermore, PTX3 deficiency results in augmented infarct area following myocardial ischemia/reperfusion injury (Salio et al., 2008), increased macrophage accumulation and inflammation in atherosclerotic plaques (Norata et al., 2009), and exacerbated proinflammatory gene expression in visceral adipose tissue from a high fat diet-induced obese mice (Guo et al., 2020). The gene discussed is PTX3; the disease is myocardial ischemia.