PTX3 and stroke disorder: Furthermore, previous studies have shown that PTX3 and miR-21-5p can reduce inflammation, including in models of brain injury and stroke (Sheedy et al., 2010; Barnett et al., 2016; Ge et al., 2016; Shindo et al., 2016; Gaudet et al., 2018; Yang et al., 2018; Rajkovic et al., 2019; Slota and Booth, 2019).