However, an anti-glycemic effect of DPP4 inhibitors is apparent in mice lacking GLP-1R (Hansotia et al., 2004), and GLP-1R antagonism does not eliminate the anti-glycemic effect of DPP4 inhibitors in patients with T2D (Nauck et al., 2016). The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.