Conversely, the frequency of ILD was significantly higher in patients with AAV not having PR3-ANCA (or C-ANCA) than in those having PR3-ANCA (or C-ANCA) (24.2% vs. 4.6%, P = 0.004). The gene discussed is PRTN3; the disease is anti-neutrophil cytoplasmic antibody-associated vasculitis.