We may suggest that partial-methylated of HeyL promoter resulted in shifting the differentiation of pulmonary epithelial cells towards ciliated cells causing the dry cough as well as shift erythroid/megakaryocyte differentiation towards platelets eliciting the ratio of platelets to lymphocytes (PLR) and proinflammatory markers including CRP, ferritin, and D-dimer, resulting in the observed fever, dry cough, and severe pneumonia in COVID-19 patients. Here, HEYL is linked to COVID-19.