Apo lipoprotein-E(APOE) encoded by APOE gene, is a plasma glycoprotein of 34.15 kDa with 299-amino acids has revealed a pivotal role in the biological processes including CAD progression [2,3].Studies discussed impairment of cholesterol efflux in CAD which has been linked to APOE4 accumulation in the endosomal compartments of the cells resulting in increased intracellular cholesterol production and atherosclerosis [4].Significant amount of research is now focused on identifying new therapeutic alternatives from herbal and botanical origin to prevent and treat this disease. Here, APOE is linked to coronary artery disorder.