OXT and Anxiety: It is hypothesised that high anxiety states result from a low oxytocin activity in brain, which could be either due a low hypothalamic expression of oxytocin gene, low levels of central oxytocin release or a low availability of oxytocin in the local extracellular fluid, impaired expression of oxytocin receptor or an insignificant binding of oxytocin to the regions of the brain concerned with emotional and social behaviours.