In gram-negative sepsis, LPS and tumor necrosis factor (TNF-α) both induced apoptosis of glomerular endothelial cells, in renal endothelial cells, TNF-α Receptor 1 induces apoptosis via a caspase-8-dependent pathway (47), and may promote sepsis-induced AKI in vivo (44, 48). This evidence concerns the gene TNF and Sepsis.