GSDMD and Sepsis: In a rat model of sepsis, Yang et al. found that the caspase-1 inhibitor AC-YVAD-CMK significantly reduced the expression of GSDMD in renal tissue, and protected against acute renal injury caused by sepsis by blocking the expression of NLRP1 inflammatory body, reducing the scorch death of RTECs induced by the inflammatory body, increasing antioxidant enzyme activity, and weakening oxidation products (83).