MLKL and acute respiratory distress syndrome: Interestingly, consistent with the executors of pyroptosis (GSDMs) or necroptosis (p-MLKL) destroying the membrane integrity by forming either pores or channels, the envelope (E) protein, another structural protein of SARS-CoV-2, can form a cation channel to induce rapid cell death in myriad susceptible cell types and robust secretion of cytokines and chemokines in macrophages resulting in acute respiratory distress syndrome (ARDS)-like damages in vitro and in vivo (Figure 1B).