RPS6KB1 and pseudolymphoma: To verify the activity of the mTOR pathway, the phosphorylation levels of AKT, 4EBP1, p70S6K, and S6K, and levels of unphosphorylated S6k were measured by immunohistochemistry in the tissue samples of 31 patients with CD and 10 patients with reactive lymphoid hyperplasia (Figure 1B).