IHC results showed that the expression levels of pAKT, p4EBP1, p70S6K, and pS6k in the tissue samples of CD patients was significantly higher than those in patients with reactive lymphoid hyperplasia (P=0.001, 0.007, 0.039, and 0.007, respectively) (Table 4A, Figure 3). The gene discussed is RPS6KB1; the disease is hyperplasia.