In particular, in 5/18 (28%) patients the gene was involved in the pathogenesis of ALPS (4 FAS, 1CASP10) and in 7/18 (39%) subject variants were implicated in ALPS-like disorders (4 TNFSF13B, 1 LRBA, 1 CTLA4, 1 STAT3). Here, STAT3 is linked to autoimmune lymphoproliferative syndrome.