Collectively, our analysis of single cell sequencing data suggested that the EGFR/MAP2K1/MTOR/TEAD1/YAP1 are highly expressed in the immune and malignant cells of TME with consequent influence on TAM-mediated immunosuppressive TME of primary and metastatic NSCLC. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.