Enrichment analysis implicated several oncological pathways including wnt signaling, astrocyte differentiation, epithelial cell proliferation, cell morphogenesis, epidermis development, wound healing, cell proliferation, keratinocyte proliferation, hippo signaling, lung epithelium development, cellular senescence and EGFR TKI resistance in the pathological role of these gene in lung cancer (Figure S1). This evidence concerns the gene EGFR and lung cancer.