Collectively, our analysis of single cell sequencing data suggested that the TME of primary tumor of NSCLC are enormously immunosuppressive than the metastatic tumor and are populated by high expression levels of EGFR/MAP2K1/MTOR/TEAD1/YAP1 within tumor microenvironment of NSCLC. Here, YAP1 is linked to non-small cell lung carcinoma.