we further investigated the expression of the genes in different states of macrophages, and the results demonstrated that genes’s expression were significantly higher in M2 macrophages compared to M0 and M1 macrophages, suggesting that EGFR/MTOR/YAP1/MAP2K1 are involved in M2 tumor associated macrophage polarization, which was an essential step for the remodeling of tumor immune microenvironment (TIME) (55). This evidence concerns the gene MAP2K1 and neoplasm.