Furthermore, we investigated the expression of EGFR/MTOR/YAP1/MAP2K1 in different states of macrophages, and the results demonstrated that genes’ expression were significantly higher in M2 macrophages compared to M0 and M1 macrophages (Figure 8A), suggesting that EGFR/MTOR/YAP1/MAP2K1 are involved in M2 polarization, an essential step for the remodeling of tumor immune microenvironment (TIME) (55). Here, MAP2K1 is linked to neoplasm.