Analysis of scRNA-seq data of metastatic NSCLC in TME revealed a higher population of malignant cells when compared to other cells including the monocyte and macrophages (2020 single cells), endothelial (221 single cells), pericytes (366 single cells), oligodendrocytes (133 single cells), plasma (117 single cells) and a few CD8 T (99 single cells) were found (Figures 7A–C). Here, CD8A is linked to non-small cell lung carcinoma.