Meta-analysis of the differentially expressed genes within each cell of the TME, revealed higher expression levels of the genes particularly the MAP2K1 and mTOR occurs in the monocytes/macrophages, Treg and exhaustive CD8 T cell within the TME of patients with primary NSCLC (Figures 6B and S2). This evidence concerns the gene MAP2K1 and non-small cell lung carcinoma.