Indeed, we found that the immune infiltration-mediating roles of EGFR/MAP2K1/mTOR/TEAD1/YAP1 led to overall decreased levels of active cytotoxic lymphocytes in NSCLC tumors and achieved shorter survival durations of cohorts with dysfunctional T-cell phenotypes. This evidence concerns the gene MAP2K1 and non-small cell lung carcinoma.